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. Author manuscript; available in PMC: 2022 Mar 29.
Published in final edited form as: Behav Brain Res. 2020 Nov 9;399:113009. doi: 10.1016/j.bbr.2020.113009

Figure 1. Impact of chronic inflammation by intraplantar CFA administration in C57BL/6J and DBA/2J mice.

Figure 1.

(A) Mechanical sensitivity by Von Frey in C57BL/6J mice that received mineral oil or 100% CFA in left hind paw. (B) Paw diameter relative to before and after injection. (C) Time-course of voluntary wheel running upon CFA administration in 120-minute session. (D) Time course of mechanical sensitivity in DBA/2J mice that received vehicle or CFA. (E) Change in paw edema diameter of ipsilateral paw pre- and post CFA administration. (F) Distance traveled by voluntary wheel running following CFA. Data are expressed as mean ± S.E.M. of n=12/group. **p<0.01, ***p<0.001 vs. vehicle.