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Proteoglycans regulate leucocyte recruitment. (A) Proteoglycans are composed of a protein core, depicted here embedded in a cell membrane as is the case with the syndecan family. Proteoglycans have glycosaminoglycan (GAG) side chains that can bind to a number of proteins, for example chemokines. (B) Proteoglycans on the surface of both endothelial cells and leucocytes regulate interactions between the two by masking adhesion molecules. Created with BioRender.com
