Table F.1.
Country | Gentamicin | Chloramphenicol | Ampicillin | Cefotaxime | Ceftazidime | Meropenem | Tigecycline | Nalidixic acid | Ciprofloxacin/pefloxacin | Azithromycin | Colistin | Sulfonamides | Trimethoprim | Trimethoprim‐sulfa | Tetracyclines | Method used | Quantitative (Q) or categorical (SIR or PWT/PNWT) | Interpretive criteria |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Austria | ● | ● | ● | ● | ● | ● | ● | ● | ●( a ) | ● | ● | ● | ● | DD | Q | Interpreted by ECDC. EUCAST ECOFFs for all except CLSI CBP for SUL | ||
Belgium | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | DL | Q | Interpreted by ECDC, as for Austria. EFSA criteria for AZM MIC | |||||
Cyprus | ● | ● | ● | ● | ● | ● | ● | ● | DL/DLG | Q | Interpreted by ECDC, as for Austria, except for CTX, MEM and SXT where EUCAST CBP were used | |||||||
Denmark | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | DL | Q | Interpreted by ECDC, as for Austria. EFSA criteria for AZM MIC | |
Estonia | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | DL | Q | Interpreted by ECDC, as for Austria | ||
Finland | ● | ● | ● | ● | ● | ● | ●( a ) | ● | ● | DD | Q | Interpreted by ECDC, as for Austria | ||||||
France | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | DL | Q | Interpreted by ECDC, as for Austria. EFSA criteria for AZM MIC | |
Hungary | ● | ● | ● | ● | ● | ● | ●( a ) | ● | ● | ● | DD | SIR | EUCAST CBP except CLSI CBP for NAL, SUL and TET | |||||
Iceland |
● | ● | ●( a ) | ● | DD | SIR | EUCAST CBP | |||||||||||
Ireland | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | WGS | PWT/PNWT | Sequencing results interpreted by the laboratory with BioNumerics tools for acquired AMR genes and point mutations | ||||
Italy | ● | ● | ● | ● | ● | ● | ● | ● | ●( a ) | ● | ● | ● | ● | ● | DD/DL | Q | Interpreted by ECDC, as for Austria | |
Latvia | ● | ● | ● | DD | SIR | No recent information on guidelines used | ||||||||||||
Luxembourg | ● | ● | ● | ● | ● | ● | ●( a ) | ● | ● | ● | ● | DD/DL/DLG | Q | Interpreted by ECDC, as for Austria | ||||
Malta | ● | ● | ● | ● | ● | ● | DL/DLG/DD | Q | Interpreted by ECDC, as for Austria | |||||||||
Netherlands | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | DL | Q | Interpreted by ECDC, as for Austria. EFSA criteria for AZM MIC | |
Norway | ● | ● | ● | ● | ● | ●( a ) | ● | DD | Q | Interpreted by ECDC, as for Austria | ||||||||
Portugal | ● | ● | ● | ● | ● | ● | ● | ● | ●( a ) | ● | ● | ● | ● | DD | Q | Interpreted by ECDC, as for Austria | ||
Romania | ● | ● | ● | ● | ● | ● | ● | ●( a ) | ● | ● | ● | ● | DD | Q | Interpreted by ECDC, as for Austria | |||
Slovakia | ● | ● | ● | ● | ● | ● | ● | ● | DD/DL | SIR | EUCAST CBP except CLSI CBP for NAL, SUL and TET | |||||||
Slovenia | ● | ● | ● | ● | ● | ● | ●( a ) | ● | ● | ● | ● | DD/DLG | Q | Interpreted by ECDC, as for Austria | ||||
Spain | ● | ● | ● | ● | ● | ● | ● | ●( a ) | ● | ● | ● | DD | Q | Interpreted by ECDC, as for Austria | ||||
Sweden | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | WGS | PWT/PNWT | Sequencing results interpreted by the laboratory with NCBI AMRFinder and CGE ResFinder and PointFinder |
AST: antimicrobial susceptibility testing; CBP: clinical breakpoint; DD: disk diffusion; DL: dilution; DLG: dilution with gradient strip; WGS: whole genome sequencing; Q: quantitative data; SIR: susceptible standard dosing regimen, susceptible increased exposure, resistant (categorical data); PWT/PNWT: predicted wild type/predicted non‐wild type (categorical); ECDC: European Centre for Disease Prevention and Control; ECOFF: epidemiological cut‐off; CLSI: Clinical and Laboratory Standards Institute; EUCAST: European Committee on Antimicrobial Susceptibility Testing; NCBI: National Center for Biotechnology Information, US; CGE: Center for Genomic Epidemiology, Denmark; MIC: minimum inhibitory concentration.
AZM: azithromycin; CTX: cefotaxime; GEN: gentamicin; MEM: meropenem; NAL: nalidixic acid; SUL: sulfonamides; TET: tetracycline.
Pefloxacin used in disk diffusion.