Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 27;12(2):220. doi: 10.3390/biom12020220

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

A phenotypic analysis of DFNA9; the calculated age of onset and annual threshold deterioration (ATD) across variants affecting cochlin within the LCCL, the Ivd1, and the vWFA2 domain. (A) ATD of the pure-tone average across PTA_0,5-4kHz with increasing age. Longitudinal data from single subjects are shown as a semi-transparent line between successive time points. A non-linear logistic fit shows the average PTA over time for the LCCL domain (blue), the Ivd1 domain (black), and the vWFA2 domain (red). (B) The parameter estimates and their 95% confidence intervals for the calculated age of onset (arbitrarily set at 25 dB) and the ATD (dB/year) for the various variants within the LCCL domain (blue), the vWFA2 domain (red), and the Ivd1 domain (black). The dashed line shows the averaged calculated onset and ATD across all variants (unweighted for differences between the number of subjects for each variant).