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Interactions between the folates cycle and the one-carbon cycle. DHFR: dihydrofalate reductase, MTHFR: methylenetetrahydrofolate reductase. MTHFD1: methylenetetrahydrofolate dehydrogenase 1. MTR: methionine synthase, MTRR: methionine synthase reductase. SAM: S-adenosylmethionine, SAH: S-adenosylhomocysteine, THF: tetrahydrafolate.
