Table 1.

Anticholinergic and sedative burden of candidate drugs. Top repositioned drugs with anticholinergic burden or sedative load are shown. Drugs are categorized as high, moderate, low, and no anticholinergic burden and sedative load based on the ACSBC cumulative scale. References of scales and metrics used in the categorization are included.

Drug Name	Anticholinergic Burden	Sedative Load
Quetiapine	Moderate [76]	Moderate [77]
Aripiprazole	Low [78,79,80]	Moderate [81]
Risperidone	Low [76,78,79,80,82,83,84,85,86,87]	Moderate [77]
Suvorexant	No	High [77]
Olanzapine	Moderate [76,82]	Moderate [77]
Travoprost	No [79]	No
Betaxolol	Low [76,79,88]	Low [77]
Ibuprofen	No [79,80,89]	Low [77]
Trifluoperazine	High [78,82]	High [77]
Trazodone	Low [76,78,79,80,82,84,86,87]	Moderate [77]
Doxepin	High [78,79,83,89,90]	Moderate [81]