Figure 1.

miRNA and RBP regulation of insulin signaling in metabolic diseases. (A) Schematic overview of miRNAs and RBPs involved in the regulation of the insulin signaling pathway. (B) Cooperation between RBPs and miRNAs. (C) General view of microRNA biogenesis. RBPs are represented in bold and miRNAs are represented in red. Black arrows represent activation processes and red lines represent inhibition processes. Note that the target genes showed in the figure are those validated experimentally, but these genes can be also modulated by other miRNAs and the miRNAs highlighted can regulate other genes that do not appear in the figure.