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. 2022 Feb 1;12(2):239. doi: 10.3390/biom12020239

Figure 6.

Figure 6

ErbB3 receptor expression in SCs. (A) qRT-PCR analysis shows that erbB3 receptor transcript levels are upregulated already after 16 h and 24 h of APE treatment (*** p < 0.001; **** p < 0.0001; n = 3); (B) Representative Western blot analysis for erbB3 receptor. The expression of the receptor is significantly downregulated after 16 and 24 h of 100 µM APE treatment. The graph shows the average ± SEM of the OD of the bands normalized against the OD of the calreticulin, used as reference protein (Figure 3B; **** p < 0.0001; n = 3). (C,D) FACS analysis for erbB3 receptor shows a significant increase in the percentage of erbB3 positive cells after PE treatment (85.5 ± 1.17; Ctrl vs. PE *** p = 0.0002; n = 3) and a decrease in erbB3 positive cells after APE treatment (28 ± 1.32; PE vs. PE + APE, **** p < 0.0001; n = 3).