ADME properties of cinnamic acid analogues.

Comp.	Solubilitya	BBBb	CYP2D6c	Hepatoxicityd	PPBe	Absorptionf	AlogP9g	PSAh
CA 1	2	1	FALSE	TRUE	TRUE	3	4.845	152.427
CA 2	2	1	FALSE	FALSE	TRUE	2	3.335	116.194
CA 3	2	1	FALSE	FALSE	TRUE	2	3.135	136.491
CA 4	2	1	FALSE	TRUE	TRUE	3	3.308	166.139
CA 5	2	1	FALSE	TRUE	TRUE	3	3.118	142.319
CA 6	2	1	FALSE	TRUE	TRUE	2	3.214	132.178
CA 7	3	1	FALSE	TRUE	TRUE	3	4.105	153.234
CA 8	2	1	FALSE	TRUE	TRUE	2	3.214	150.178
CA 9	3	1	FALSE	TRUE	TRUE	2	3.578	146.714
CA 10	2	1	FALSE	TRUE	TRUE	3	3.468	150.546
CA 11	2	1	FALSE	TRUE	TRUE	2	3.752	162.482
CA 12	3	1	FALSE	TRUE	TRUE	3	3.312	138.814
CA 13	2	1	FALSE	TRUE	TRUE	2	3.562	157.178
CA 14	2	1	FALSE	TRUE	TRUE	2	3.421	142.278
ACA 1	2	1	FALSE	TRUE	TRUE	3	3.308	126.139
ACA 2	2	1	FALSE	TRUE	TRUE	3	3.178	143.116
ACA 3	3	1	FALSE	TRUE	TRUE	3	3.751	148.142
ACA 4	2	1	FALSE	TRUE	TRUE	3	3.892	156.178
CATD 1	2	1	FALSE	TRUE	TRUE	3	2.932	143.911
CATD 2	1	1	FALSE	FALSE	TRUE	4	4.513	137.954
CATD 3	2	1	FALSE	FALSE	TRUE	3	4.113	147.954
CATD 4	4	1	FALSE	FALSE	TRUE	4	2.625	150.491
CATD 5	1	1	FALSE	FALSE	TRUE	4	4.357	157.954
FMCV	2	1	FALSE	TRUE	TRUE	3	2.549	150.055
P02	2	2	FALSE	TRUE	TRUE	3	4.951	150.89

^aSolubility level – 0 extremely low; 1 no very low but possible; 2 yes low; 3 yes good; 4 yes optimal; 5 no too soluble.

^bBBB – blood-brain barrier level – 0 very high; 1 high; 2 medium; 3 low; 4 undefined.

^cCYP2D13 – cytochrome 450 inhibition.

^dHepatotoxicity.

^ePPB – plasma-protein binding.

^fAbsorption – 1 very poor, 2 poor; 3 medium; 4 good.

^gAlogP98 – partition coefficient of octanol/water system,

^hPSA – polar surface area.