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. 2022 Feb 8;12(2):276. doi: 10.3390/biom12020276

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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APR-246 enhances the responses of NAX053 in MIA-PaCa-2 when WT-TP53 is present, while APR-236 has less effects on the responses of NAX054 on MIA-PaCa-2 cells in the presence of WT-TP53. Panel (A) MIA-PaCa-2 + pLXSN cells treated with different concentrations of NAX053 (red squares) or with different concentrations of NAX053 and a low dose of APR-246 (blue triangles). Panel (B) MIA-PaCa-2 + WT-TP53 cells treated with different concentrations of NAX053 (red squares) or with different concentrations of NAX053 and a low dose of APR-246 (blue triangles). Panel (C) MIA-PaCa-2 + pLXSN cells treated with different concentration of NAX054 (red squares) or with different concentrations of NAX054 and a low dose of APR-246 (blue triangles). Panel (D) MI-PaCa-2 + WT-TP53 cells treated with different concentrations of NAX054 (red squares) or with different concentrations of NAX054 and a low dose of APR-246 (blue triangles). The measurements were repeated 4 times, and similar results were observed. *** = p < 0.0001, ** = p < 0.005.