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. 2022 Feb 8;12(2):276. doi: 10.3390/biom12020276

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Chemical structures of BBR and NAX compounds and the potential effects of the mutant TP53 reactivator APR-246 to increase their toxicity of MIA-PaCa-2 + pLXSN and MIA-PaCa-2 + WT-TP53 cells. Abilities of APR-246 to interact with BBR and NAX compounds and to cause increased growth inhibition in MIA-PaCa-2 cells either in the presence of GOF m-TP53 or GOF-mTP53 + introduced WT-TP53. Mut-TP53, mutant TP53. (A) = Berberine, (B) = NAX012, (C) = NAX014, (D) = NAX035, (E) = NAX038, (F) = NAX042, (G) = NAX053, (H) = NAX054, (I) = NAX060, (J) = NAX075, (K) = NAX077, (L) = NAX111.