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. 2022 Feb 8;12(2):276. doi: 10.3390/biom12020276

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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APR-246 enhances the effects of NAX014 greater when WT-TP53 is present in PANC-28 cells, while APR-246 enhances the effects of NAX035 in PANC-28 cells in the presence of WT-TP53 but not in the absence of WT-TP53. Panel (A) PANC-28 + pLXSN cells treated with different concentrations of NAX014 (red squares) or with different concentrations of NAX014 and a low dose of APR-246 (blue triangles). Panel (B) PANC-28 + WT-TP53 cells treated with different concentrations of NAX014 (red squares) or with different concentrations of NAX014 and a low dose of APR-246 (blue triangles). Panel (C) PANC-28 + pLXSN cells treated with different concentrations of NAX035 (red squares) or with different concentrations of NAX035 and a low dose of APR-246 (blue triangles). Panel (D) PANC-28 + WT-TP53 cells treated with different concentrations of NAX035 (red squares) or with different concentrations of NAX035 and a low dose of APR-246 (blue triangles). The measurements were repeated 3 times, and similar results were observed. *** = p < 0.0001, ** = p < 0.005, NS, not statistically significant.