Skip to main content
. 2022 Feb 8;12(2):276. doi: 10.3390/biom12020276

Figure 18.

Figure 18

Chemical structures of BBR and NAX compounds and the potential effects of the mutant TP53 reactivator APR-246 to increase their toxicity of PANC-28 + pLXSN and PANC-28 + WT-TP53 cells. Abilities of APR-246 to interact with BBR and NAX compounds and cause increased growth inhibition in PANC-28 cells either in the presence of non-expressed (TP53 null) or the same cells with introduced WT-TP53. (A) = Berberine, (B) = NAX012, (C) = NAX014, (D) = NAX035, (E) = NAX038, (F) = NAX042, (G) = NAX053, (H) = NAX054, (I) = NAX060, (J) = NAX075, (K) = NAX077, (L) = NAX111.