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Optic nerve damage in DBA2/J mice. (A) Examples of optic nerve damage grades. A grade of 1 indicates a normal optic nerve, whereas a grade of 4 is assigned to optic nerves displaying severe damage and numerous PPD stained axons (arrows) and areas of gliosis (arrowhead). (B) Grading of optic nerve damage demonstrates a protective effect in pioglitazone (Pio)-treated mice (p = 0.0334). Each dot represents one optic nerve. *: p < 0.05.
