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Pioglitazone improves visual acuity in glaucomatous mice. Induction of elevated IOP following baseline measurements leads to a decrease in OKR. Pioglitazone treatment after one month (early treatment, red line) caused a reversal of these deficits. Pioglitazone treatment in mice with more advanced damage (late treatment group, blue line) prevents further functional decline and partially reverses losses. Arrows indicate the start of pioglitazone treatments. ** p < 0.01; * p > 0.05.
