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. 2022 Mar 11;13:827274. doi: 10.3389/fgene.2022.827274

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Copyright © 2022 Dvoriantchikova, Lypka and Ivanov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The DNA demethylation process is associated with photoreceptor development. (A) Hypermethylated promoters of genes required for photoreceptor specification/maturation/function show DNA demethylation during the differentiation of RPCs into photoreceptors. (B) The analysis of the methylation dynamics of individual cytosine bases in the promoter (1,000 bp) and first exon (500 bp) regions of photoreceptor genes revealed that cytosines close to a transcription start site (TSS) were mostly affected. (E/RPCs—embryonic retina/RPCs; P/PHRs—postnatal mature retina/photoreceptors).