Figure 4.

Main differences in miR expression in tumors compared to cardiovascular tissues. These changes in miR expression support the shift from high oxidative stress to low oxidative stress, from Th1/Th2 to Th2/Treg with more activated MDSC and less activated NK cells, and from M1 macrophage to M2 macrophage inflammation, ultimately leading to less apoptosis in tumors. The downregulation of miRs is possibly due to the overexpression of lncRNAs and circ-RNAs summarized in Table 1. Upregulated non-coding RNAs are in brown, down-regulated ones in blue.