Table 3.
Univariable and multivariable analyses of variables associated with recurrence-free survival.
| Characteristic * | Univariable Analysis | Multivariable Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-Value | HR | 95% CI | p-Value | |
| Age (years) | ||||||
| <65 vs. ≥65 | 1.25 | 0.91–1.71 | 0.164 | 1.74 | 1.24–2.44 | 0.001 |
| Tumor size | ||||||
| 1 vs. 2 (3.1–5.9 cm) | 0.87 | 0.59–1.30 | 0.500 | 0.92 | 0.61–1.41 | 0.711 |
| 1 vs. 3 (≥6 cm) | 1.19 | 0.79–1.81 | 0.406 | 1.82 | 1.16–2.85 | 0.010 |
| Lymph node ratio | 10.1 | 4.95–20.6 | <0.001 | 6.82 | 3.20–14.5 | <0.001 |
| Perineural invasion | ||||||
| No vs. Present | 2.73 | 1.96–3.80 | <0.001 | 2.90 | 2.03–4.16 | <0.001 |
| Neoadjuvant CCRT | ||||||
| No vs. Yes | 1.68 | 1.10–2.55 | 0.016 | 2.35 | 1.46–3.81 | <0.001 |
Abbreviations: HR, hazard ratio; CI, confidence interval; vs., versus; 1, ≤3.0 cm; 2, 3.1–5.9 cm; 3, ≥6 cm; CCRT, chemoradiotherapy. * The variables were previously identified through either the ML models or conventional statistical analyses.