Table 3.

Maximal adverse event for the dose interruption and non-shift interval groups.

Adverse event	Arm (n = 30)				p-value
	Dose interruption (n = 9)		Non-shift interval (n = 21)
	Any adverse event	CTC grade 2, 3, 4, or 5	Any adverse event	CTC grade 2, 3, 4, or 5
Rash	6 (20%)	3 (10%)	10 (33%)	3 (10%)	0.44
Elevated ALT	8 (26%)	2 (6%)	12 (40%)	6 (20%)	0.20
Elevated AST	9 (30%)	2 (6%)	11 (36%)	0 (0%)	0.01
Dry skin	3 (10%)	0 (0%)	1 (3%)	0 (0%)	0.11
Paronychia	0 (0%)	0 (0%)	1 (3%)	1 (3%)	>0.99
Anemia	0 (0%)	0 (0%)	1 (3%)	0 (0%)	>0.99
Nausea	0 (0%)	0 (0%)	1 (3%)	0 (0%)	>0.99
Diarrhea	1 (3%)	0 (0%)	1 (3%)	0 (0%)	0.52
Oral ulcer	0 (0%)	0 (0%)	1 (3%)	0	>0.99