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. 2022 Mar 11;13:819080. doi: 10.3389/fimmu.2022.819080

Figure 1.

Figure 1

Landscape of m6A methylation regulators in GBM. (A) Graphical summary of this study. The graphical summary was created with BioRender. (B) Heatmap of differential expression of m6A methylation regulators (Normal= 160, Tumor = 169; Normal sample from GTEx dataset, Tumor sample from TCGA-GBM dataset). (C) Mutation frequency of 15 m6A methylation regulators. (D) CNV variation frequencies of m6A methylation regulators in the TCGA-GBM cohort. Column height represents change frequency. Green indicates loss. Red indicates gain. (E) Chromosomal locations of altered CNV in the m6A regulators in the TCGA-GBM cohort. (F) Principal component analysis of the 15 m6A methylation regulators in normal and GBM patients (Red indicates normal and blue indicates GBM patients; Normal sample from GTEx dataset, GBM sample from TCGA-GBM dataset). *, **, and *** indicate p = < 0.05, < 0.01, and < 0.001, respectively.