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. 2022 Mar 11;13:819080. doi: 10.3389/fimmu.2022.819080

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Copyright © 2022 Xiong, Li, Wan, Zheng, Zhang, Wang and Fan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of the tumor microenvironment in the two m6A methylation patterns. (A) Unsupervised clustering analysis in GBM meta cohort. (B) Kaplan-Meier OS analysis in the two m6A clusters. P = 0.011. (C) GSVA enrichment analysis in the two m6A clusters. Red indicates pathway activation. Blue indicates pathway inhibition. (D) Differential of immune function between the two m6A clusters. (E) Abundance of Immune cell abundance in the two m6A clusters. (F)Enrichment score of common stromal activation pathways in the two m6A clusters.*, **, and *** indicate p = < 0.05, < 0.01, and < 0.001, respectively. ns, not significant. Upper and lower ends of the boxes indicate interquartile range. The lines in the boxes represent the median values.