Table 3. IC50 (μM) of Compounds 1 and 3–13 Using the MTT Assaya.
| compound | Jurkat | A549 | A375 | MCF-7 | HaCaT |
|---|---|---|---|---|---|
| 1 | >10 | >10 | >10 | >10 | >10 |
| 3 | >10 | >10 | >10 | >10 | >10 |
| 4 | >10 | >10 | >10 | >10 | >10 |
| 5 | >10 | >10 | >10 | >10 | >10 |
| 6 | >10 | >10 | >10 | >10 | >10 |
| 7 | >10 | >10 | >10 | >10 | >10 |
| 8 | 7.7 ± 0.45 | 8.9 ± 0.60 | >10 | >10 | 2.9 ± 0.57 |
| 9 | >10 | >10 | >10 | >10 | >10 |
| 10 | 5.0 ± 0.59 | >10 | 3.7 ± 0.47 | 9.6 ± 0.52 | 1.6 ± 0.21 |
| 11 | 4.7 ± 0.45 | 4.1 ± 0.11 | >10 | >10 | 1.7 ± 0.55 |
| 12 | >10 | >10 | >10 | >10 | 3.5 ± 0.27 |
| 13 | >10 | >10 | >10 | >10 | >10 |
| Spb | 3.2 ± 0.93 | 9.1 ± 1.20 | 2.1 ± 0.90 | 6.3 ± 0.55 | 1.6 ± 0.60 |
a
Data are expressed as IC50 (μM) values indicating the concentration of each compound that inhibits cell growth by 50% as compared to control cells.
b
Sp: Staurosporin (0.2 μM) was used as a positive control.