Table 4.

Logistic regression model: risk factors associated with the composite endpoint (transfer to ICU for more than 24 h or hospital death)

Variables	Univariate analysis		Multivariate analysis
	OR [95% CI]	p-value	OR [95% CI]	p-value
Sex
Female	0.77 [0.45–1.29]	0.33	0.78 [0.44–1.35]	0.37
Male	Ref		Ref
Age
> 60 years	1.80 [1.06–2.11]	0.031	2.14 [1.22–3.85]	0.0093
≤ 60 years	Ref		Ref
Charlson comorbidity index
> 3	2.59 [1.54–4.39]	< 0.001	3.17 [1.80–5.69]	< 0.001
≤ 3	Ref		Ref
Hematological disease
Acute myeloid leukemia	1.37 [0.75–2.40]	0.29	1.67 [0.82–3.34]	0.15
Other	Ref		Ref
Cause of hospitalization
Intensive or induction chemotherapy	1.12 [0.57–2.06]	0.74	0.99 [0.45–2.08]	0.99
Other	Ref		Ref
At least one febrile episode during hospital stay
Yes	2.53 [1.48–4.44]	< 0.001	3.10 [1.75–5.67]	< 0.001
No	Ref		Ref
Period
Post-intervention period	0.41 [0.23–0.72]	0.0025	0.29 [0.15–0.53]	< 0.001
Pre-intervention period	Ref		Ref

Results of both univariate and multivariate analyses are presented

OR: Odds-ratio; ref: reference