Table 1.
Demographics of patients with BM
| total CRC N = 25 | colon cancer N = 11 | rectal cancer N = 14 | |||||
|---|---|---|---|---|---|---|---|
| Number (%) | mean (min-max) | Number (%) | mean (min-max) | Number (%) | mean (min-max) | ||
| patient characteristics | |||||||
| gender, female | 6 (24.00) | 5 (45.45) | 1 (7.14) | ||||
| age at first diagnosis, yr | 61.88 (30–81) | 59.91 (30–81) | 63.43 (51–78) | ||||
| age at first diagnosis, > 63 yr | 10 (40.00) | 4 (36.36) | 6 (42.86) | ||||
| body mass index, kg/cm2 | 26.1 (19.1–41.6) | 26.3 (19.1–41.6) | 25.9 (22.0–32.4) | ||||
| high blood pressure | 13 (52.00) | 7 (63.64) | 6 (42.86) | ||||
| alcohol consumption | 2 (8.00) | 0 | 2 (14.29) | ||||
| smoking history | 2 (8.00) | 1 (9.09) | 1 (7.14) | ||||
| convulsion | 6 (24.00) | 1 (9.09) | 5 (35.71) | ||||
| cardiovascular disease | 7 (28.00) | 4 (36.36) | 3 (21.43) | ||||
| diabetes mellitus type II | 4 (16.00) | 4 (36.36) | 0 | ||||
| second malignoma | 2 (8.00) | 1 (9.09) | 1 (7.14) | ||||
| chronic kidney injury | 4 (16.00) | 2 (18.18) | 2 (14.29) | ||||
| chronic obstructive pulmonic disease | 4 (16.00) | 2 (18.18) | 2 (14.29) | ||||
| cardiac stents | 1 (4.00) | 0 | 1 (7.14) | ||||
| adipositas | 4 (16.00) | 2 (18.18) | 2 (14.29) | ||||
| colorectal cancer | |||||||
| UICC stage | n/a | 2 (8.00) | 0 | 2 (14.29) | |||
| I | 3 (12.00) | 1 (9.09) | 2 (14.29) | ||||
| II | 1 (4.00) | 1 (9.09) | 0 | ||||
| III | 10 (40.00) | 6 (54.55) | 4 (28.57) | ||||
| IV | 9 (36.00) | 3 (27.27) | 6 (42.86) | ||||
| Grading | n/a | 2 (8.00) | 1 (9.09) | 1 (7.14) | |||
| G1 | 9 (36.00) | 6 (54.55) | 3 (21.43) | ||||
| G2 | 8 (32.00) | 3 (27.27) | 5 (35.71) | ||||
| G3 | 6 (24.00) | 1 (9.09) | 5 (35.71) | ||||
| pulmonary metastasis | 18 (72.00) | 7 (63.64) | 11 (78.57) | ||||
| time from first diagnosis to pulmonary metastasis, mo | 33.44 (0–103) | 37.43 (0–82) | 30.91 (0–703) | ||||
| liver metastasis | 15 (60.00) | 8 (72.73) | 7 (50.00) | ||||
| time from first diagnosis to liver metastasis, mo | 19.27 (0–98) | 30.29 (0–98) | 9.63 (0–40) | ||||
| other systemic metastasis (without brain) | 9 (36.00) | 3 (27.27) | 6 (42.86) | ||||
| number chemotherapeutic drugs | 3.08 (0–8) | 3.64 (0–8) | 2.64 (0–7) | ||||
| systemic chemotherapy | w/o | 2 (8.00) | 0 | 2 (14.29) | |||
| adjuvant | 14 (56.00) | 11 (100.00) | 3 (21.43) | ||||
| neoadjuvant + adjuvant | 9 (36.00) | 0 | 9 (64.29) | ||||
| systemic radiation therapy | w/o | 14 (56.00) | 8 (72.73) | 6 (42.86) | |||
| neoadjuvant | 4 (16.00) | 0 | 4 (28.57) | ||||
| adjuvant | 7 (28.00) | 3 (27.27) | 4 (28.57) | ||||
| brain metastasis | |||||||
| age at diagnosis of BM, yr | 65.80 (36–82) | 64.27 (36–82) | 67.00 (51–78) | ||||
| time from first diagnosis to BM, mo | 47.16 (0–102) | 52.91 (5–95) | 42.64 (0–102) | ||||
| number of BMs | 1 | 14 (56.00) | 9 (81.82) | 5 (35.71) | |||
| 2 | 3 (12.00) | 0 | 3 (21.43) | ||||
| 3 | 6 (24.00) | 1 (9.09) | 5 (35.71) | ||||
| > 3 | 2 (8.00) | 1 (9.09) | 1 (7.14) | ||||
| localization of BM | cerebral | 9 (36.00) | 6 (54.55) | 3 (21.43) | |||
| cerebellar | 6 (24.00) | 3 (27.27) | 3 (21.43) | ||||
| both | 10 (40.00) | 2 (18.18) | 8 (57.14) | ||||
| symptoms of BM | incidental finding | 4 (16.00) | 3 (27.27) | 1 (7.14) | |||
| unspecific CNS | 3 (12.00) | 3 (27.27) | 0 | ||||
| specific CNS | 18 (72.00) | 5 (45.45) | 13 (92.86) | ||||
| radiation therapy, brain | 17 (68.00) | 7 (63.64) | 10 (71.43) | ||||
| radiation therapy, modality | stereotactic | 11 (64.71) | 5 (71.43) | 6 (60.00) | |||
| whole brain | 6 (35.29) | 2 (28.57) | 4 (40.00) | ||||
| radiation dose, Gy | 38.31 (25–71) | 33.50 (25–45) | 41.20 (30–71) | ||||
| surgery | |||||||
| localization surgery | cerebral | 11 (45.83) | 6 (54.55) | 5 (38.46) | |||
| cerebellar | 13 (54.17) | 5 (45.45) | 8 (61.54) | ||||
| cross total resection | 13 (54.17) | 8 (72.73) | 5 (38.46) | ||||
| age at death, yr | 66.20 (37–81) | 62.56 (37–81) | 69.18 (51–79) | ||||
| time from first diagnosis to death, mo | 51.75 (5–104) | 56.44 (9–704) | 47.91 (5–95) | ||||
| time from BM to death, mo | 4.90 (0–18) | 6 (0–18) | 4 (0–9) | ||||
| time from BM to death, mo [median] | 3.00 (0–18) | 3 (0–18) | 2 (0–9) | ||||
| six-month survival, mo | 8 (40.00) | 3 (33.33) | 5 (45.45) | ||||
| one-year survival, mo | 2 (10.00) | 2 (22.22) | 0 | ||||
BM brain metastasis, CI confidence interval, CRC colorectal cancer, CNS central nervous system, G grading, Gy Gray, HR Hazard ratio, KPS Karnofsky performance status, Mo months, MRC-NPS Medical Research Council Neurological Performance Ccore, N number, n/a not applicable, OS Overall survival, UICC Union for International Cancer Control, Yr years, w/o without