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Kinetic parameters of the purified β-lactamase CME-2
| Drug | kcat (s−1) | Km (μM) | kcat/Km (μM−1 · s−1) |
|---|---|---|---|
| Cephaloridine | 30.6 | 23.4 | 1.31 |
| Benzylpenicilllin | 12.3 | 7.4 | 1.66 |
| Amoxicillin | 6.7 | 26.5 | 0.26 |
| Ticarcillin | 1.8 | 5.8 | 0.31 |
| Piperacillin | 0.3 | <1 | —a |
| Cephalothin | 60.6 | 41.5 | 1.46 |
| Cefoxitin | <0.01 | — | — |
| Cefuroxime | 57.3 | 81.6 | 0.70 |
| Cefoperazone | 2.6 | 3.8 | 0.68 |
| Cefotaxime | 12.1 | 20.8 | 0.58 |
| Ceftazidime | 23.6 | 125 | 0.19 |
| Aztreonam | 3.2 | 10.5 | 0.31 |
| Imipenem | <0.01 | — | — |
—, not detectable.
