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. 2022 Mar 29;14:35. doi: 10.1186/s13073-022-01037-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Responder colonized mice show anti-tumor immune phenotype following treatment with immunotherapy. Half of the resected subcutaneous allograft tumors from human microbiota colonized responder and non-responder mice (n = 9/group) were subjected to single-cell dissociation and flow cytometric analysis for A tumoral CD8+ IFNγ+ T cells as represented by percent of total intra-tumoral CD8+ T cells in responder (n = 8) and non-responder (n = 9) tumors, Mann-Whitney P = 0.049; B tumoral CD4+ CXCR3+ T cells as represented by percent of total CD4+ T cells in responder (n = 7) and non-responder (n = 9) tumors, Mann-Whitney P = 0.012; C tumoral neutrophils (Gr1+ CD11c+ CD11b+ cells) as represented by percent of total live cells in responder (n = 8) and non-responder (n = 9) tumors, Mann-Whitney P = 0.039; and D tumoral macrophages (Gr1− CD11c− CD11b+ cells) as represented by percent of total live cells in responder (n = 8) and non-responder (n = 9) tumors, Mann-Whitney P = 0.035