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. 2022 Mar 29;237:108991. doi: 10.1016/j.clim.2022.108991

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© 2022 Published by Elsevier Inc.

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Fig. 4 — CD4 + CTLs are the most expanded CD4 + T cell subset in COVID-19 lungs.

(A) Representative multi-color immunofluorescence images of CD4 (red), SLAMF7 (green) and DAPI (blue) staining in a lung from a COV-19 patient. Arrows indicate SLAMF7+ CD4 + CTLs. (B) Absolute numbers and relative proportions of SLAMF7+ CD4 + CTLs in lungs from early (purple) (n = 8) and late (blue) (n = 8) COV-19 patients and non-COV-19 patients (green) (n = 6). (C) Representative multi-color immunofluorescence images of CD4 (red), CX3CR1 (green) and DAPI (blue) staining in a lung from a COV-19 patient. (D) Absolute numbers and relative proportions of CX3CR1+ CD4 + CTLs in lungs from early (purple) (n = 8) and late (blue) (n = 8) COV-19 patients and non-COV-19 patients (green) (n = 6). Multiple comparisons are controlled for by Kruskal-Wallis test. *p < 0.05; **p < 0.01. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)