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. 2022 Mar 29;237:108991. doi: 10.1016/j.clim.2022.108991

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© 2022 Published by Elsevier Inc.

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Fig. 5 — Epithelial cells and endothelial cells express HLA class II in severe COVID-19.

(A) Representative multi-color immunofluorescence images of Pan-CK (orange), CD31 (green), CD4 (red), HLA-DR (purple) and DAPI (blue) staining in a lung from a COV-19 patient. White and yellow boxes highlight HLA-DR+ CD31+ endothelial cells (left) and HLA-DR+ Pan-CK+ epithelial cells (right). CD4+ T cells are observed in close proximity to HLA-DR+ endothelial cells and epithelial cells. (B) Relative proportions of HLA-DR+ endothelial cells (left) and epithelial cells (right) in lungs from early (purple) (n = 4) and late (blue) (n = 5) COV-19 and non-COV-19 patients (green) (n = 5). (C) Representative multi-color immunofluorescence images of cleaved-caspase3 (c-Casp3) (green) and DAPI (blue) staining in lungs from COV-19 patients (upper) and non-COV-19 patients (lower). (D) Absolute numbers of total c-Casp3+ cells in lungs from early (purple) (n = 8) and late (blue) (n = 8) COV-19 patients and non-COV-19 patients (green) (n = 6). (E) Representative multi-color immunofluorescence images of CD68 (purple), ASC1 (green) and DAPI (blue) staining in a lung from a COVID-19 patient. (F) Absolute numbers of CD68+ cells in lungs from early (purple) (n = 8) and late (blue) (n = 8) COVID-19 and non-COVID-19 patients (green) (n = 6). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)