Table 1.
Description of the extension of the Human Genome Epidemiology Network’s Venice criteria to assess genetic main effect
| Criteria of consideration | Category | Proposed operationalization |
|---|---|---|
| Amount of evidence | A | Sample size over 1000 |
| B | Sample size 100–1000 | |
| C | Sample size under 100 | |
| Replication | A | I2 < 50% |
| B | 25% < I2 < 50% | |
| C | I2 > 50% | |
| Protection from bias | A | Consideration biases such as bias in genotyping, population stratification, and Selective reporting biases |
| B | Bias in genotype definition = Not reported what was done/No quality control checks/Appropriate quality control checks | |
| C |
Population stratification = Not reported what was done/Nothing done/Same descent group/Adjustment for reported descent/Family-based design/Genomic control, PCA or similar method Selective reporting biases = Meta-analysis of published data/Retrospective efforts to include unpublished data/Meta-analysis within consortium |
Evidence is classified as strong, moderate, and weak. When scored A in every criteria, evidence is categorized as strong. When scored no C in every criteria but no AAA, evidence is categorized as moderate. Weak evidence is recorded with C in one out of three criteria