Table 2.
The clinical characteristics and 30-day outcomes of patients with skin and soft tissue infections
| Sex | Age | Underlying condition | CR | ANC (109/L) |
Duration of neutropenia (Days) | Clinical presentation | Sites of involvement | Necrotizing SSTI | Shock | Pathogen | CR-Aeromonas | CA or HA | Empirical therapy | Appropriate initial empirical treatment | Outcomes | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 4 | AA | NA | 0.21 | 24 | Persistent groin pain | Groin | N | N | Aeromonas sobria | Y | CA | CAZ, SMZ | N | Death |
| 2 | F | 6 | ALL | N | 0.01 | 18 | Serve pain, skin bullae and necrosis | Lower limbs and perineum | Y | Y | Aeromonas sobria | N | HA | MEM | Y | Death |
| 3 | M | 21 | MDS | N | 0 | 10 | Serve pain, muscle swelling and necrosis | Lower limbs | Y | N | Aeromonas hydrophila | Y | CA | IPM | N | Death |
| 4 | M | 12 | ALL | N | 0.03 | 12 | Serve pain, muscle swelling and necrosis | Lower limbs and buttocks | Y | N | Aeromonas hydrophila | Y | HA | MEM | N | Amputation |
| 5 | M | 13 | AA | NA | 0 | 4 | Red papules and firm nodules in skin with pain | The four limbs | N | N | Aeromonas hydrophila | Y | HA | SCF | Y | Survival |
| 6 | M | 27 | AML | CR | 0.05 | 7 | Unilateral lower limb pain and muscle swelling | Unilateral lower limb | N | N | Aeromonas hydrophila | Y | HA | IPM | N | Survival |
| 7 | M | 27 | AA | NA | 0.07 | 15 | Serve pain, ecchymoses, necrosis | Starts at the knees and ankles then spreads throughout the body | Y | Y | Aeromonas sobria | Y | HA | IPM | N | Death |
| 8 | M | 51 | ALL | N | 0 | 10 | Skin swelling, bullae formation and necrosis | Lower limbs, abdomen and perineum | Y | Y | Aeromonas hydrophila | Y | HA | MEM、IPM | N | Death |
| 9 | M | 54 | AA | NA | 0.03 | 18 | Rhabdomyolysis: muscle pain, weakness, and dark urine | Muscles and multiple organs | Y | Y | Aeromonas hydrophila | Y | HA | MEM | N | Death |
| 10 | M | 63 | AA | NA | 0.28 | 24 | Muscle pain and swelling | Lower limbs | N | N | Aeromonas sobria | Y | HA | IPM | N | Survival |
| 11 | M | 30 | AML | N | 0.27 | 21 | Muscle pain | Lower limbs | N | N | Aeromonas hydrophila | NA | HA | MEM | NA | Survival |
| 12 | M | 30 | ALL | N | 0.04 | 22 | Balanoposthitis | Genitals | N | N | Aeromonas hydrophila | NA | HA | MEM | NA | Survival |
| 13 | M | 11 | ALL | N | 0.01 | 18 | Subcutaneous abscess on the left abdomen | Abdomen | N | N | Aeromonas hydrophila | NA | HA | SCF, MEM | NA | Survival |
| 14 | M | 27 | AML | CR | 0 | 41 | Skin swelling, bullae formation and necrosis | The four limbs | Y | Y | Aeromonas sobria | NA | HA | IPM, TZP, CIP | NA | Death |
CR complete remission, ANC absolute neutrophil count, M male, F female, CA community-acquired, HA hospital-acquired, AML acute myeloid leukemia, ALL acute lymphoblastic leukemia, AA aplastic anemia, MDS myelodysplastic syndromes, CAZ ceftazidime, MEM meropenem, IPM imipenem, SMZ timethoprim–sulphamethoxazole, SCF cefoperazone/sulbactam, TZP piperacillin/tazobactam, CIP ciprofloxacin, NA not applicable or detected, CR-Aeromonas carbapenem resistant-Aeromonas