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. 2022 Mar 26;26:82. doi: 10.1186/s13054-022-03956-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Effects of different PEEP titration strategies on P_driv and Ptp_driv during supine and prone positioning. A P_driv evaluated according to different PEEP titration strategies during supine and prone positioning. B Ptp_driv evaluated according to different PEEP titration strategies during supine and prone positioning. Bars are means + SD of 40 patients with moderate to severe ARDS. Brackets denote statistically significant differences between PEEP titration strategies strategies, p-values are shown above the brackets. P_driv driving pressure, PEEP positive end-expiratory pressure, PEEP_ARDSNetwork PEEP titrated according to the ARDS Network lower PEEP table, PEEP_Estat,RS PEEP titrated according to the lowest elastance of the respiratory system, PEEP_Ptpexp PEEP titrated according to end-expiratory transpulmonary pressure, Ptp_driv transpulmonary driving pressure pressure