Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 28;15:37. doi: 10.1186/s13045-022-01253-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — Multiplex immunohistochemistry of cholangiocarcinomas. A Overlaid multiple images stained with immune cell markers with pseudocolors and selected immune cell subtypes defined by multiple myeloid cell marker were shown. B Percentages of immune cell subtypes among CD45⁺ cells. C–E Immune cell composition according to the average percentages of each type of immune cells among CD45⁺ cells in three different types of cholangiocarcinoma divided into the group of OS < 3 years and the group of OS > 3 years. The percentages of each cell type were compared between the groups of OS < 3 years and OS > 3 years by t test. *p < 0.05; **p < 0.01. F–K Kaplan–Meier curves of overall survival of patients whose tumors are grouped by higher density versus lower density of CD8⁺ T cells or CD8⁺granzyme B⁺ T cell subtypes as indicated. Log rank tests were done with p values indicated. DCC, distal cholangiocarcinoma; HC, hilar cholangiocarcinoma; ICC, intrahepatic cholangiocarcinoma