Fig. 4.

The role of tumor associated macrophages (TAM) or PD-L1+ TAM in the overall survival of cholangiocarcinoma. Kaplan–Meier curves of overall survival (OS) of patients whose tumors are grouped by higher density versus lower density of different types of TAMs or PD-L1⁺ TAM as indicated. The correlation of the density of M1-TAM (A–C), M2-TAM (D–F), PD-L1+ M1-TAM (G–I), PD-L1⁺M2-TAM (J–L), and PD-L1⁺CSF-1R⁺ myeloid cells (M–O) with OS. Log rank tests were performed with p values as indicated. DCC, distal cholangiocarcinoma; HC, hilar cholangiocarcinoma; ICC, intrahepatic cholangiocarcinoma