Table 1.

Property change encoding

Property	Measured unit	Threshold	Threshold in $lo{g}_{10}$ scale	Designed property change tokens
LogD	-	-	-	LogD_change_(− inf, − 6.9]
				...
				LogD_change_(− 0.3, − 0.1]
				LogD_change_(− 0.1, 0.1]
				LogD_change_(0.1, 0.3]
				...
				LogD_change_(6.9, inf]
Solubility	$\mu$M	low: $\le$50	low: $\le$1.7	Solubility_low$\to$high
		high: >50	high: >1.7	Solubility_high$\to$low
				Solubility_no_change
Clearance	$\mu$L/min/mg	low: $\le$20	low: $\le$1.3	Clearance_low$\to$high
		high: >20	high: >1.3	Clearance_high$\to$low
				Clearance_no_change