Table 6.

Test sets where big property changes (logD change is above 1; solubility and clearance change is either low$\to$high or high$\to$low) are desired

Test set	Size	Percentage (%)
MMP	6,180	3.7
Similarity ($\ge$0.5)	18,546	3.9
Similarity ([0.5, 0.7))	15,130	4.6
Similarity ($\ge$0.7)	3,416	2.3
Scaffold	6,252	3.1
Scaffold generic	10,514	3.6
Merged	21,652	-

Size indicates the number of data points where big property change are desired; Percentage indicates the fraction of the original test set in Table 2 with data points that have big property changes, e.g. 6180/166582$\approx$3.7%