TABLE 1.
Effect of treatment of mice with hM-CSF and AMPH-B on in vitro C. albicans growth-inhibitory activities of macrophagesa
| Treatment | [3H]glucose incorporation (cpm [% inhibition]) |
|---|---|
| None (C. albicans only) | 11,107.0 ± 468.3 |
| Vehicle | 7,153.7 ± 2,258.9 (35.6) |
| hM-CSF (4 × 106 U/kg) | 4,225.7 ± 724.7 (62.0) |
| AMPH-B (100 μg/kg) | 5224.7 ± 900.0 (53.0) |
| hM-CSF + AMPH-B | 2843.0 ± 479.5 (74.4)b |
a
Macrophages were prepared from mice administered hM-CSF and/or AMPH-B. After incubating macrophages and C. albicans (E/T, 25:1) for 16 h, [3H]glucose incorporation into viable C. albicans was determined. Data are expressed as mean ± standard deviation counts per minute and represent the percent incorporation inhibition for triplicate samples.
b
P < 0.05 (significant difference among the treatments). The results for all treatment were significantly different from those of no treatment.