Table 1.
Characteristics of participants and rats in control (con) and diabetic nephropathy (DN) groups
| Variable | Con | DN | p-Value |
|---|---|---|---|
| Human | |||
| Male (%) | 53% | 70% | 0.7160 |
| Age (years) | 52.38 ± 15.06 | 53.82 ± 9.23 | 0.7475 |
| BMI (kg/m2) | 25.34 ± 2.96 | 24.61 ± 2.65 | 0.4789 |
| SBP (mmHg) | 140.8 ± 17.68 | 148.1 ± 23 | 0.3362 |
| DBP (mmHg) | 77.5 ± 8.94 | 80.56 ± 14.79 | 0.4978 |
| FBG (mmol/L) | 5.42 ± 1.19 | 10.43 ± 5.14 | < 0.001 |
| CREA (umol/L) | 88.76 ± 32.45 | 193.7 ± 105.3 | < 0.001 |
| CCr (mL/min) | 103.1 ± 31.04 | 54.75 ± 25.93 | < 0.0001 |
| 24hUTP (mg) | 353.8 ± 134.58 | 2415 ± 1662.56 | < 0.0001 |
| UA (umol/L) | 309.9 ± 76.07 | 421.1 ± 42.58 | < 0.0001 |
| TP (g/L) | 72.3 ± 8.51 | 60.5 ± 7.83 | < 0.0001 |
| Rats | |||
| FBG (mmol/L) | 5.5 ± 0.6 | 23.6 ± 4.2 | < 0.0001 |
| CREA (umol/L) | 21.4 ± 4.3 | 45.6 ± 9.7 | < 0.0001 |
| BUN (mmol/L) | 2.5 ± 0.5 | 6.8 ± 0.9 | < 0.0001 |
| 24hUTP (mg) | 45.6 ± 6.1 | 320.5 ± 68.3 | < 0.0001 |
Data presented as mean ± SD. BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; FBG, fasting blood glucose; CREA, creatinine; CCr, creatinine clearance; 24hUTP, 24-h urinary protein quantity; UA, uric acid; TP, total protein; BUN, blood urea nitrogen