TABLE 1.
Activities of mutacin B-Ny266, nisin A, vancomycin, and oxacillin against gram-positive bacteria
| Organism (no. of strains) | MICa (μg/ml) of:
|
|||
|---|---|---|---|---|
| Mutacin B-Ny266 | Nisin A | Vancomycin | Oxacillin | |
| Micrococcus spp. (4) | 0.05 (0.03–0.08) | 1.1 (0.3–16.7) | 1.0 (0.5–2.0) | 2.1 (0.01–4.2) |
| Enterococcus spp. (12) | 12.8 (1.6–25.6) | 16.7 (8.4–33.4) | 3.9 (1.9–>120) | 11.9 (4.2–63.4) |
| Listeria spp. (23) | 0.8 (0.4–2.0) | 4.2 (1.1–16.7) | 1.0 (0.3–2.1) | 4.2 (0.5–15.9) |
| Staphylococcus spp. (19) | 1.6 (0.1–18.1) | 4.2 (1.5–83.6) | 3.8 (0.3–15.1) | 7.9 (0.1–>127) |
| Streptococcus spp. (17) | 0.4 (0.03–6.4) | 8.4 (0.3–83.6) | 0.5 (0.3–1.0) | 0.1 (0.02–1.1) |
| Bacillus spp. (5) | 0.8 (0.01–6.4) | 4.2 (0.01–10.5) | 0.5 (0.1–0.5) | 0.3 (0.002–>127) |
| Clostridium spp. (4) | 0.2 (0.01–3.2) | 1.1 (0.1–4.2) | 0.5 (0.3–4.0) | 1.1 (0.1–4.2) |
| Actinomyces viscosus (2) | 0.4 (0.4–0.8) | 83.6 (41.8–83.6) | 0.5 (0.5–1.0) | 0.5 (0.5–0.8) |
| Peptostreptococcus spp. (2) | 0.4 (0.2–0.8) | 2.1 (1.1–2.1) | 0.5 (0.5–1.0) | 0.3 (0.1–0.5) |
| Corynebacterium diphtheriae (1) | 0.4 (0.4–0.8) | 4.2 (4.2–8.4) | 1.0 (0.5–1.0) | 2.1 (1.1–2.1) |
| Gardnerella vaginalis (1) | 0.03 (0.01–0.05) | 1.1 (1.1–2.1) | 0.4 (0.3–0.5) | 0.1 (0.07–0.1) |
| Mycobacterium smegmatis (2) | 32 (25–70) | 8.4 (7.4–15) | 8.0 (8.0–15) | 95.1 (63.4–126.8) |
| Propionibacterium acnes (2) | 1.2 (0.8–1.6) | 2.1 (1.1–4.2) | 1.0 (0.5–1.0) | 0.5 (0.5–1.1) |
a
The MIC data are expressed as the median (range) obtained from at least three independent repetitions for each strain.