TABLE 4.

Activities of mutacin B-Ny266, nisin A, vancomycin, and oxacillin against nisin-resistant mutants

Antimicrobial substance	MICa (μg/ml) for:
	Listeria monocytogenes Scott A			Pediococcus acidilactici
	HPB 3	Nisin-resistant mutantsb		UL5	Nisin-resistant mutantsc
		ATCC 700301	ATCC 700302		R1	R1M	T5
Mutacin B-Ny266	1.6 (0.8–1.6)	1.0 (0.8–1.6)	1.4 (0.8–1.6)	0.4 (0.2–0.4)	0.8 (0.8–0.8)	3.2 (3.2–3.2)	1.6 (1.6–1.6)
Nisin A	5.9 (4.2–10.5)	16.7 (16.7–16.7)	16.7 (16.7–16.7)	0.03 (0.02–0.07)	6.8 (3.7–8.4)	41.8 (23.6–47.3)	41.8 (41.8–41.8)
Vancomycin	1.4 (1.0–2.0)	1.0 (1.0–1.0)	1.0 (1.0–1.0)	>120	>120	>120	>120
Oxacillin	7.9 (5.6–8.5)	1.5 (1.5–2.1)	2.6 (2.1–3.0)	7.9 (7.9–15.9)	4.0 (2.8–4.2)	2.8 (2.0–3.0)	2.1 (2.0–4.0)

^aThe MIC data are expressed as the median (range) obtained from at least three independent repetitions. 

^bNisin-resistant mutants were obtained from Crandall and Montville (3) and Mazzotta et al. (23). 

^cNisin-resistant mutants were obtained from Goulhen et al. (11).