TABLE 5.
Activities of mutacin B-Ny266, nisin A, vancomycin, and oxacillin against other lantibiotic-producing strains
| Producing strain | Lantibiotic produced | MICa (μg/ml) of:
|
|||
|---|---|---|---|---|---|
| Mutacin B-Ny266 | Nisin A | Vancomycin | Oxacillin | ||
| Bacillus subtilis ATCC 6633 | Subtilin | 1.6 (1.0–1.6) | 8.4 (8.4–10.5) | 0.5 (0.3–0.5) | 0.5 (0.5–0.5) |
| Lactococcus lactis subsp. lactis ATCC 11454 | Nisin A | 1.0 (0.8–1.6) | 27.2 (20.9–33.4) | 0.5 (0.5–1.0) | 2.1 (1.1–4.2) |
| Lactococcus lactis subsp. lactis biovar diacetylactis UL719 | Nisin Z | 0.8 (0.8–1.6) | 33.4 (33.4–41.8) | 1.0 (0.5–1.0) | 4.0 (3.0–4.2) |
| Staphylococcus epidermidis DSM 3095 | Epidermin | 12.8 (8.7–18.1) | 83.6 (66.9–83.6) | 8.0 (7.5–15.1) | 0.2 (0.1–0.3) |
| Staphylococcus gallinarum DSM 4616 | Gallidermin | 1.6 (1.6–1.6) | 2.1 (2.1–3.0) | 2.0 (2.0–2.0) | 0.8 (0.8–1.1) |
| Streptococcus mutans BHT | Mutacin b | 0.8 (0.4–0.8) | 16.7 (8.4–16.7) | 0.5 (0.5–0.5) | 0.2 (0.2–0.4) |
| Streptococcus mutans 32K | Mutalipocin | 0.8 (0.8–1.6) | 83.6 (41.8–83.6) | 0.8 (0.5–1.0) | 0.1 (0.1–0.3) |
| Streptococcus mutans JH1140 | Mutacin B-JH1140 | 1.6 (0.8–1.6) | 41.8 (41.8–83.6) | 1.0 (1.0–1.0) | 0.05 (0.05–0.1) |
| Streptococcus mutans Ny266 (ATCC 202022) | Mutacin B-Ny266 | 4.8 (3.2–6.4) | 33.4 (16.7–33.4) | 1.0 (1.0–1.0) | 0.1 (0.03–0.1) |
a
The MIC data are expressed as the median (range) obtained from at least three independent repetitions.