Table 1.
Summary of major clinical trials.
| TRIAL | Inclusion Criteria | Number of Patients | Mean/Median Age |
Median NIHSS | IV tPA | Re Perfusion |
sICH | mRS Less than 2 at 90 Days | limitation | Mortality 90 Days |
|---|---|---|---|---|---|---|---|---|---|---|
| MR CLEAN | NIHSS > 2, occlusion of vessel imaging |
500 I: 233 C:267 |
I:65.8 C65.7 |
I: 17 C: 18 |
I: 87.1 C:90.6 |
58.7 | I 7.7 C6.4 |
I 32.6 C 19.1 |
No perfusion imaging. Low reperfusion rate |
I:18.9 C:18.4 At 30 days |
| ESCAPE | NIHSS > 5, ASPECT > 6, collateral assessment, stent retriever in 84% | 315 I 165 C150 |
I 71 C 70 |
I 16 C 17 |
I 72.7 C 78.7 |
72.4% | I 3.6 C2.7 |
I 53 C29.3 |
No perfusion imaging | I: 10.4 at 90 days C 19% |
| EXTEND IA | Age > 18 y Collateral assesment, perfusion imaging |
70 I 35 C 35 |
I 78.6 C 70.2 |
I 17 C 13 |
I 100 C 100 |
86% | I 0 C 6 |
I 71 C 40 |
Small sample size | I 9% C 20% |
| SWIFT PRIME | NIHSS 8–29 ASPECT > 6 Perfusion imaging |
196 I 98 C 98 |
I 65 C 66.3 |
I 17 C 17 |
I 100 C 100 |
83% | I 0 C 3 |
I 16 C 35 |
All patients received IVT | I 9 C12 |
| REVASCAT | NIHSS > 6 ASPECT > 6 AGE 18–85 years |
206 I 103 C 103 |
I 65.7 C 67.2 |
I 17 C 17 |
I 68 C 77 |
65.6% | I 4.9 C1.9 |
I 43.7 C28.2 |
Low reperfusion rate | I: 18.4% C:15.5% |
| DAWN | NIHSS > 10 Core and clinical mismatch Up to 24 h |
206 I 107 C 99 |
I 69.4 C 70.7 |
I 17 C 17 |
I 5 C 13 |
84% | I 6 C 3 |
I 49 C 13 |
Severe stroke, Difference in baseline variables | I 19 C 18 |
| DIFFUSE 3 | Perfusion with mismatch 6–16 |
182 I 92 C 90 |
I 70 C 71 |
I 16 C 16 |
I 11 C 9 |
76% | I 7% C 4% |
I 45% C 17% |
Patient papulation is older. | I 14% C 26% |