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. 2022 Feb 21;10(2):505. doi: 10.3390/biomedicines10020505

Figure 2.

Figure 2

IGF-1 prevented the death of the PCs in the cerebellum of the SCA3 84Q mice. (a) The arrows indicate the PCs located at the PCL (right panel). The average number of the PCs per 100 μm in the posterior lobules of the cerebellum is presented in the bar graph (mean ± SEM) (left panel). SCA3 15Q, n = 6; SCA3 84Q, n = 8; SCA3 84Q + IGF-1, n = 8. (b) Western blot analysis of calbindin (left panel). Relative expression levels of calbindin in the cerebellum (mean ± SEM) (right panel). SCA3 15Q, n = 4; SCA3 84Q, n = 4; SCA3 84Q + IGF-1, n = 4. (c) The lines indicate the distance from the tip of the granular layer (GL) to the white matter (right panel). Histogram showing the thickness of the GL (mean ± SEM) (left panel). SCA3 15Q, n = 5; SCA3 84Q, n = 6; SCA3 84Q + IGF-1, n = 8. (d) The frames are the sampling area of the Figure and the lines refer to the distance from the PCL to the edge of the molecular layer (ML) (right panel). Histogram showing the thickness of the ML (mean ± SEM) (left panel). SCA3 15Q, n = 5; SCA3 84Q, n = 6; SCA3 84Q + IGF-1, n = 8. Note: * p < 0.05 indicates a significant difference.