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. 2022 Feb 9;10(2):407. doi: 10.3390/biomedicines10020407

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Synthesis, receptor and signaling of 20-HETE. Arachidonic metabolism by CYP450 hydroxylases in different species (shown: human, mouse and rat) convert arachidonic acid into 20-HETE (and 19-HETE). 20-HETE is a ligand of G-protein-coupled receptor GPR75 and activates PLC, PKC, c-Src-EGFR, ACE leading to vasoconstrictive and natriuretic effects. 20-HETE can be further metabolized by CYP-epoxygenases, LOX and COX. UDP-glucuronosyltransferases metabolizes 20-HETE to form glucuronides in humans.