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Synthesis, receptor, and signaling of EETs. Arachidonic acid is converted into four EET regioisomers by species-specific CYP450 epoxygenases (human, mouse, and rat isoforms shown). GPR40, shown in the box under EETs, is a GPCR activated by EETs, resulting in activation of signaling pathways and cellular effects of EETs. EETs are metabolized by soluble epoxide hydrolase (sEH) to form corresponding dihydroxyeicosatrienoic acids (DHET) with much lower activity.
