Figure 3.

The Nuclear Factor kB (NF-kB) pathways activation: the canonical pathway (triggered by the action of tumor necrosis α, TNFα; interleukin 1, IL-1, and lipopolysaccharides, LPS, on T cell receptor, TCR, with involvement of transforming growth factor activating kinase—B, TAK1; the kB inhibitor complex kinase α, β, IKK α, β; of the essential modulator of NF-kB, IkB-α, β, ε kB inhibitor family, Nemo), the non-canonical pathway (involving NF-κB-induced kinase, NIK, and IKK γ) and the atypical pathway.