Figure 1.
The estimated latent variable model for the effect of oral contraceptive (OC) and hormonal intrauterine device (HIUD) use on baseline 5-HT4R BPND in women with an untreated depressive episode. γ is the effect on the global latent variable interpreted as global (log-transformed) 5-HT4R BPND effects. λ is the loading on each region. The boxes beneath the loadings indicate the percentage difference in 5-HT4R binding for each brain region in OC- and HIUD users compared to non-users. Regional bindings were adjusted for Age, BMI, 5-HTTLPR genotype and injected tracer mass per kg bodyweight (not shown). P-values and confidence intervals are adjusted for 3 comparisons by use of the Dunnett’s test.