ACE1 |
angiotensin I-converting enzyme, |
ACE2 |
angiotensin-converting enzyme 2, |
Ang-II |
angiotensin II, |
Ang-I |
angiotensin I, |
Ang 1–7 |
angiotensin 1–7, |
APS |
antiphospholipid syndrome, |
ARBs |
angiotensin II receptor blockers, |
AT1R |
angiotensin type 1 receptor, |
AUC0–6h
|
area under the curve, |
CAD |
coronary artery disease, |
CCBs |
calcium channel blockers, |
Cmax |
maximum concentration, |
CSG |
Coronaviridae Study Group, |
CYP |
cytochrome P450, |
DDIs |
drug–drug interactions, |
E |
envelope, |
ECMO |
extracorporeal membrane oxygenation, |
EMA |
European Medicines Agency, |
EUA |
Emergency Use Administration, |
FDA |
Food and Drug Administration, |
JAK-STAT |
Janus kinase and signal transducer and activator of transcription, |
Kb |
kilobases |
ICU |
intensive care unit, |
IDSA |
Infectious Diseases Society of America, |
IL-6 |
interleukin-6, |
INR |
international normalized ratio, |
LQTs |
long Q-T syndromes, |
M |
membrane, |
MERS-CoV |
Middle East respiratory syndrome coronavirus, |
Mpro |
main protease, |
N |
nucleoprotein, |
NHC-TP |
β-D-N4-hydroxycytidine 5′-triphosphate, |
nsp-3 |
nonstructural protein 3, |
ORF |
open reading frames, |
PAD |
peripheral artery disease, |
PLpro |
papain-like protease, |
RAAS |
renin-angiotensin-aldosterone system, |
RCTs |
randomized clinical trials, |
RdRp |
RNA-dependent RNA polymerase, |
RNA |
ribonucleic acid, |
RTP |
remdesivir triphosphate, |
SARS-CoV |
severe acute respiratory syndrome coronavirus, |
SARS-CoV-2 |
severe acute respiratory syndrome coronavirus 2, |
TMPRSS2 |
transmembrane serine protease 2, |
UTR |
untranslated regions, |
VF |
ventricular fibrillation, |
VT |
ventricular tachycardia, |
WHO |
World Health Organization, |
WT |
wild-type, |
3CLPRO |
3C-like protease. |