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. 2022 Feb 18;10(2):486. doi: 10.3390/biomedicines10020486

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Enhanced anti-tumor effects of folate-targeted liposomal nitrooxy-DOXorubicin against resistant tumors. (A) Tumor growth until 21 days: control (ctrl); effect of free DOX (D); effect of Caelyx; effect of nitrooxy-DOXorubicin (ND); liposomal nitrooxy-DOXorubicin (LND); folate-targeted liposomal nitrooxy-DOXorubicin (LNDF). Data are presented as means ± SD. ND/LND/LNDF vs. ctrl group: * p < 0.01; ND/LND/LNDF vs. D: ° p < 0.01; LNDF vs. ND: # p < 0.001; LNDF vs. LND: § p < 0.05; (B) Pictures of representative tumors from each treatment group after mice sacrifice. Reprinted from [39] with permission from Elsevier, 2021.