Table 1.
The function, expression, and target of USP15 in various cancers and other diseases.
| Function | Cancer/Disease | Expression of USP15 | Target |
|---|---|---|---|
| Proliferation, migration, and invasion |
Breast cancer | Up [60] | BMI1 [70], ER𝛂 [71] |
| Multiple myeloma | Up [62] | NF-κB/p65 [62] | |
| Gastric cancer | Up [65] | IκBα [74] | |
| Colon cancer | Up [76] | MDM2 [76], p53 [77] | |
| Hepatocellular carcinoma | Up [78] | KEAP1 [79] | |
| Prostate cancer | Up [63] | IRS-2 [82,83] | |
| Glioblastoma multiforme | Up [60] | SMURF2 [86], TβR-I [60,87] | |
| Leiomyosarcoma | DEK [85] | ||
| Hypertrophic scar | TβR-I [88] | ||
| Osteoarthritis | ERK2 [89] | ||
| Wound healing | EIF4A1 [90] | ||
| Apoptosis | Chronic myeloid leukemia | Up [68] | Caspase-6 [91] |
| Procaspase-3 [92] | |||
| FKBP5 [93] | |||
| Autophagy | Parkinson’s disease | Up [96] | PARKIN [96,97] |
| Cell cycle | REST [100,101,102] | ||
| Genome integrity | Ovarian cancer | Up [61] | BARD1 [54] |
| Leukemia | Up [68] | FUS [68] | |
| H2B [104] | |||
| TOP2A [53] | |||
| Transcriptional regulation | Neurodegenerative diseases | TUT1 [105] | |
| R-SMAD [106] | |||
| PRP31 [107] | |||
| SLIM1 [108] | |||
| Immune response | Melanoma | Up [76] | TET2 [109] |
| Human papillomavirus | E6 [111], TRIM25 [116,117] | ||
| TBK1 [115] | |||
| Others | ALK3 [123] | ||
| BRAP [124] |