Figure 4.

(a,b) Cytotoxicity of α₁-acid glycoprotein-conjugated hyaluronic acid nanoparticles (AGP-HA NPs) at 48 h and 72 h incubation time using a CCK-8 kit, and LPS mediates DOX-resistance in MDA-MB-231 cells at various concentrations of α₁-acid glycoprotein-conjugated hyaluronic acid nanoparticles (AGP-HA NPs) (50, 100, and 300 µg/mL) at 48 and 72 h incubation time All data presented in averages and standard deviations from at least three independent experiments. Statistical analysis was determined using Student’s t-test (*** p < 0.001, ** p < 0.01).